DO_MGI_slim DO_FlyBase_slim NCIthesaurus disease of metabolism amyloidosis NCI:C2868 MESH:D000686 A disease of metabolism that is characterized by extracellular tissue deposition of mis-folded amyloid fibrils built up by twisted protofilaments, deposited in the spaces between the cells of vital organs, causing disruption of organ tissue structure and function. These deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition. ICD9CM:277.3 SNOMEDCT_US_2025_09_01:154769007 ICD10CM:E85 disease_ontology UMLS_CUI:C0002726 MESH:D000686 DOID:9120 amyloid disease amyloidosis has both inherited and acquired subtypes [LS].