structural similarity evidence A type of similarity evidence based on structural similarity of an annotated gene or gene product to another gene or group of genes. ECO:0000027 The secondary structure of VapC10 (Figure S2), predicted with the 3DJIGSAW prediction tool [36] and the DALI server [37], exhibited homology with several well studied VapC toxins, such as the first PIN domain structure for the protein PAE2754 from the archae bacterium Pyrobaculum aerophilum (30). eco For GO annotation, in the case of a single gene, an accession for the related gene's sequence is entered in the evidence_with field. phenotypic similarity evidence