realizes is_specified_output_of concretizes chromatin immunoprecipitation evidence chromatin immunoprecipitation-chip evidence A type of chromatin immunoprecipitation evidence that uses a tiling microarray for the detection of protein-bound DNA regions where chromatin is immunoprecipitated for protein tagging and DNA is sheared from the cross-linked protein-DNA complex to be arrayed revealing the protein-bound genomic regions. A fixating agent such as formaldehyde is used to cross link proteins and DNA. Sonication is applied for DNA shearing. For transcription factor tagging, an antibody or epitope is employed. After cross-linking is reversed, the DNA is amplified and labeled with a flourophore for microarray which produces a resolution of aproximately 500 bp. eco ECO:0000230 ChIP-on-chip evidence MI:0225 CollecTF mchibucos ChIP-chip evidence 2010-11-16T05:43:55Z assay ChIP-chip assay ChIP-chip design