biological system reconstruction evidence biological system reconstruction evidence based on inference from background scientific knowledge snadendla 2015-12-18T15:32:15Z A type of biological system reconstruction based solely on background scientific knowledge of that biological system. eco ECO:0005548 The available knowledge is usually a combination of partial or weak experimental evidence where either some components are missing or no physical interaction evidence can be found but the system is inferred by similarity to related systems in taxonomically-disparate organisms with experimental evidence. Functional studies or ligand binding evidence are often used for the reconstruction of biological systems. It does not provide physical interaction evidence but uses proxies such a ligand binding evidences to infer the presence or absence of the complex components.