mass spectrometry evidence protein hydrogen-deuterium exchange mass spectrometry evidence ECO:0006195 DisProt:BalintMeszaros snadendla A type of mass spectrometry evidence derived from measuring changes in mass associated with the isotopic exchange between amide hydrogens of the protein backbone and its surrounding solvent, providing information on the structural state, the dynamics and the intrinsic chemical properties of the underlying amino acid sequence. eco HDX-MS