has role primary carboxamide gilteritinib A member of the class of pyrazines that is pyrazine-2-carboxamide which is substituted by {3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}nitrilo, (oxan-4-yl)nitrilo and ethyl groups at positions 3,5 and 6, respectively. It is a potent inhibitor of FLT3 and AXL tyrosine kinase receptors (IC<small>₅₀</small> = 0.29 nM and 0.73 nM, respectively). Approved by the FDA for the treatment of acute myeloid leukemia in patients who have a FLT3 gene mutation. CHEBI:145372 renoprotective agent monomethoxybenzene piperidines aromatic amine antineoplastic agent pyrazines N-methylpiperazine oxanes secondary amino compound EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor apoptosis inducer