has role GS-441524 A C-nucleoside analog that is (2<i>R</i>,3<i>R</i>,4<i>S</i>,5<i>R</i>)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile substituted by a 4-aminopyrrolo[2,1-<em>f</em>][1,2,4]triazin-7-yl group at position 2. It is the active metabolite of remdesivir and exhibits a broad range of inhibitory activity against various RNA viruses including HCV, parainfluenza and SARS-CoV. CHEBI:147281 anticoronaviral agent nitrile aromatic amine C-nucleoside drug metabolite pyrrolotriazine