has role independent continuant secondary carboxamide colibactin CHEBI:156303 A member of the class of 1,3-thiazoles that comprises of two units of 2-[(2-{6-[(2<i>S</i>)-2-methyl-3,4-dihydro-2<em>H</em>-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)methyl]-1,3-thiazole-4-carboxylic acid linked together via the formal condensation of the carboxy groups. It is a secondary metabolite produced by certain strains of bacteria found in the human gut such as <em>Escherichia coli</em>. It has the ability to bind covalently to DNA and is strongly associated with colorectal cancer. alkylating agent pyrroline polyketide azaspiro compound 1,3-thiazoles carcinogenic agent Escherichia coli metabolite