has role levomethadone dextromethadone (S)-(+)-methadone chebi_ontology S-methadone PMID:30907440 d-methadone d-6-(dimethylamino)-4,4-diphenyl-3-heptanone PMID:31454827 (6S)-6-(dimethylamino)-4,4-diphenylheptan-3-one PMID:21175445 0 PMID:23935979 PMID:23249875 REL-1017 309.453 Chemspider:559067 USSIQXCVUWKGNF-KRWDZBQOSA-N PMID:32302325 Wikipedia:Dextromethadone PMID:27055456 (+)-(S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone (+)-methadone (S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone PMID:31091116 S-(+)-methadone InChI=1S/C21H27NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17H,5,16H2,1-4H3/t17-/m0/s1 CCC(=O)C(C[C@H](C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1 Reaxys:3213667 A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder. PMID:29458047 CHEBI:167308 CAS:5653-80-5 (S)-methadone (6S)-methadone C21H27NO PMID:31368772 PMID:27456067 PMID:27974484 309.20926 PMID:33345336 DrugBank:DB15198 6-(dimethylamino)-4,4-diphenylheptan-3-one opioid analgesic NMDA receptor antagonist