has role is deprotonated form of guanidines amiloride CHEBI:2639 A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid. aromatic amine diuretic antihypertensive agent immunosuppressive agent organochlorine compound pyrazines sodium channel blocker amiloride(1+)