has role is protonated form of has functional parent L-glutamic acid antifibrotic agent glutamic acid derivative pteridines monocarboxylic acid amide antipsychotic agent cardiovascular drug antineoplastic agent dicarboxylic acid immunosuppressive agent gout suppressant antimalarial methotrexate CHEBI:44185 methotrexate(1-) EC 1.5.1.3 (dihydrofolate reductase) inhibitor abortifacient antipsoriatic DNA synthesis inhibitor anti-HIV agent anti-asthmatic agent ophthalmology drug anti-inflammatory agent anti-anaemic agent