has role independent continuant anticoronaviral agent N-carbamoyl-amino acid carbamate ester renoprotective agent antitubercular agent antineoplastic agent vasodilator agent HIV protease inhibitor antihypertensive agent xenobiotic antiviral drug carboxamide antimalarial 1,3-thiazoles ritonavir An <small>L</small>-valine derivative that is <small>L</small>-valinamide in which α-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2<i>R</i>,4<i>S</i>,5<i>S</i>)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP<small>₃</small>A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. CHEBI:45409 insulin-sensitizing drug anti-HBV agent environmental contaminant L-valine derivative