has role is protonated form of has functional parent independent continuant phenylureas secondary carboxamide suramin(6-) benzamides antinematodal drug antineoplastic agent naphthalene-1,3,5-trisulfonic acid trypanocidal drug naphthalenesulfonic acid EC 2.7.11.13 (protein kinase C) inhibitor GABA-gated chloride channel antagonist suramin CHEBI:45906 A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. angiogenesis inhibitor GABA antagonist ryanodine receptor agonist apoptosis inhibitor purinergic receptor P2 antagonist