<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/ECTO?iri=http://purl.obolibrary.org/obo/CHEBI_4659"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://purl.obolibrary.org/obo/chebi/"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_173085 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_173085">
        <rdfs:label>ferroptosis inducer</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_24127 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_24127">
        <rdfs:label>fungicide</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35487 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35487">
        <rdfs:label>EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35489 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35489">
        <rdfs:label>organic disulfide</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35610 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35610">
        <rdfs:label>antineoplastic agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_37733 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_37733">
        <rdfs:label>EC 3.1.1.8 (cholinesterase) inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_39298 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_39298">
        <rdfs:label>organosulfur acaricide</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_4659 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_4659">
        <rdfs:label>disulfiram</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35489"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_39298"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35487"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_68495"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_48422"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_73240"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78444"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_37733"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50276"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_173085"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35610"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_24127"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>PMID:34012274</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Antabuse</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>tetraethylthioperoxydicarbonic diamide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:25565438</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25445071</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19787200</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26239994</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>LINCS:LSM-5467</oboInOwl:hasDbXref>
        <ns5:inchi>InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3</ns5:inchi>
        <oboInOwl:hasRelatedSynonym>1,1&#39;-dithiobis(N,N-diethylthioformamide)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:C01692</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>tetraethylthiuram disulfide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:32971817</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:32963852</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25495604</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26235918</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25657800</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:4659</oboInOwl:id>
        <ns5:inchikey>AUZONCFQVSMFAP-UHFFFAOYSA-N</ns5:inchikey>
        <oboInOwl:hasDbXref>PMID:16880974</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19782464</oboInOwl:hasDbXref>
        <ns5:smiles>S(SC(N(CC)CC)=S)C(N(CC)CC)=S</ns5:smiles>
        <oboInOwl:hasDbXref>PMID:26517513</oboInOwl:hasDbXref>
        <ns5:formula>C10H20N2S4</ns5:formula>
        <oboInOwl:hasDbXref>Reaxys:1712560</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25557293</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:34045896</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17079463</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:14978246</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25777347</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26314552</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:16666414</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24496638</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:31151194</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Disulfiram</oboInOwl:hasExactSynonym>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasExactSynonym>1,1&#39;,1&#39;&#39;,1&#39;&#39;&#39;-[disulfanediylbis(carbonothioylnitrilo)]tetraethane</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>PMID:16661923</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26033731</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>HMDB:HMDB0014960</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Wikipedia:Disulfiram</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25464072</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15709459</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>bis(diethylthiocarbamoyl) disulfide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:18579431</oboInOwl:hasDbXref>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasRelatedSynonym>N,N,N&#39;,N&#39;-tetraethylthiuram disulfide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:10841824</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:21471244</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>tetraethylthiuram disulphide</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Tetraethylthiuram disulfide</oboInOwl:hasRelatedSynonym>
        <ns5:mass>296.544</ns5:mass>
        <oboInOwl:hasDbXref>PMID:8442800</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25476326</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11716515</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Drug_Central:928</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:11005259</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17579916</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:33731397</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:19720750</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:26550292</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17667894</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:D00131</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>MetaCyc:DISULFIRAM</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:16426571</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:25133664</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:8572926</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:97-77-8</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Pesticides:disulfiram</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:15325261</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid.  A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties.</ns4:IAO_0000115>
        <oboInOwl:hasDbXref>DrugBank:DB00822</oboInOwl:hasDbXref>
        <ns5:monoisotopicmass>296.05093</ns5:monoisotopicmass>
        <oboInOwl:hasDbXref>PMID:26224731</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_48422 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48422">
        <rdfs:label>angiogenesis inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50276 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50276">
        <rdfs:label>EC 5.99.1.2 (DNA topoisomerase) inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_68495 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_68495">
        <rdfs:label>apoptosis inducer</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_73240 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_73240">
        <rdfs:label>NF-kappaB inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_78444 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78444">
        <rdfs:label>EC 3.1.1.1 (carboxylesterase) inhibitor</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



