<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/ECTO?iri=http://purl.obolibrary.org/obo/CHEBI_5778"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://purl.obolibrary.org/obo/chebi/"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://www.w3.org/XML/1998/namespacestring -->

    <rdfs:Datatype rdf:about="http://www.w3.org/XML/1998/namespacestring"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35358 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35358">
        <rdfs:label>sulfonamide</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35498 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35498">
        <rdfs:label>diuretic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35674 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35674">
        <rdfs:label>antihypertensive agent</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35703 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35703">
        <rdfs:label>xenobiotic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_36683 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_36683">
        <rdfs:label rdf:datatype="http://www.w3.org/XML/1998/namespacestring">organochlorine compound</rdfs:label>
        <rdfs:label>organochlorine compound</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50265 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50265">
        <rdfs:label>benzothiadiazine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_5778 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_5778">
        <rdfs:label>hydrochlorothiazide</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35358"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_36683"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50265"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35703"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35674"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78298"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35498"/>
            </Restriction>
        </rdfs:subClassOf>
        <ns5:mass>297.73900</ns5:mass>
        <oboInOwl:hasRelatedSynonym>Esidrix (TN)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>HMDB:HMDB0001928</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB00999</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24849193</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.</ns4:IAO_0000115>
        <oboInOwl:hasDbXref>Wikipedia:Hydrochlorothiazide</oboInOwl:hasDbXref>
        <ns5:smiles>NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl</ns5:smiles>
        <ns5:inchi>InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)</ns5:inchi>
        <oboInOwl:hasExactSynonym>6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide</oboInOwl:hasExactSynonym>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasDbXref>KEGG:D00340</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>hydrochlorothiazidum</oboInOwl:hasRelatedSynonym>
        <ns5:formula>C7H8ClN3O4S2</ns5:formula>
        <oboInOwl:hasDbXref>Drug_Central:1385</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:C07041</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:5778</oboInOwl:id>
        <oboInOwl:hasDbXref>LINCS:LSM-5308</oboInOwl:hasDbXref>
        <ns5:monoisotopicmass>296.96448</ns5:monoisotopicmass>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>hydrochlorothiazide</oboInOwl:hasRelatedSynonym>
        <ns5:inchikey>JZUFKLXOESDKRF-UHFFFAOYSA-N</ns5:inchikey>
        <oboInOwl:hasRelatedSynonym>hidroclorotiazida</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PDBeChem:HCZ</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24657333</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24055851</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Reaxys:625101</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:58-93-5</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_78298 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78298">
        <rdfs:label>environmental contaminant</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



