has part has role independent continuant antineoplastic agent hydrochloride prodrug EC 5.99.1.2 (DNA topoisomerase) inhibitor irinotecan hydrochloride (anhydrous) A hydrochloride obtained by combining irinotecan with one molar equivalent of hydrochloric acid. Used (in the form of its trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. CHEBI:5971 apoptosis inducer irinotecan(1+)