has role is protonated form of N-acyl-L-glutamic acid antifibrotic agent antineoplastic agent pyrrolopyrimidine EC 1.5.1.3 (dihydrofolate reductase) inhibitor pemetrexed CHEBI:63616 An <em>N</em>-acylglutamic acid in which the <em>N</em>-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1<em>H</em>-pyrrolo[2,3-<em>d</em>]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). EC 2.1.1.45 (thymidylate synthase) inhibitor EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor pemetrexed(2-)