has role polypeptide neurotransmitter peptide hormone biomacromolecule corticotropin-releasing hormone corticotropin-releasing factor PMID:6267699 chebi_ontology Wikipedia:Corticotropin-releasing_hormone CHEBI:65311 CRH PMID:22494987 A family of peptide hormones derived from a 191-membered prehormone, secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. The first full sequence was discovered in sheep, those in rats and humans differ from the ovine sequence by 7 amino acids.