has role alkylating agent monocarboxylic acid amide antineoplastic agent prodrug temozolomide An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma. Drug_Central:2589 PMID:23377829 0 M & B 39831 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide CCRG 81045 PMID:23389760 CHEBI:72564 PMID:23362460 PMID:23246370 HMDB:HMDB0014991 KEGG:D06067 TMZ CCRIS 8996 MB 39831 temozolomida 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide Patent:DE3231255 BRN 5547136 194.05522 temozolomide DrugBank:DB00853 Temodal BPEGJWRSRHCHSN-UHFFFAOYSA-N 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one M&B 39831 Wikipedia:Temozolomide 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide PMID:22680781 Reaxys:5547136 NSC 362856 PMID:23293540 methazolastone chebi_ontology Temodar Cn1nnc2c(ncn2c1=O)C(N)=O PMID:23254891 C6H6N6O2 CAS:85622-93-1 InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13) Sch 52365 PMID:22818211 PMID:23385995 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide LINCS:LSM-4590 194.15080 CCRG-81045 temozolomidum PMID:23335050 imidazotetrazine triazene derivative