<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/ECTO?iri=http://purl.obolibrary.org/obo/CHEBI_7465"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://purl.obolibrary.org/obo/chebi/"
     xmlns:chebi2="http://purl.obolibrary.org/obo/chebi#"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_134688 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_134688">
        <rdfs:label>naltrexone(1+)</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35488 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35488">
        <rdfs:label>central nervous system depressant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35703 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35703">
        <rdfs:label>xenobiotic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_38164 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_38164">
        <rdfs:label>organic heteropentacyclic compound</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50137 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50137">
        <rdfs:label>mu-opioid receptor antagonist</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_51454 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_51454">
        <rdfs:label>cyclopropanes</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_7465 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_7465">
        <rdfs:label>naltrexone</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_38164"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_51454"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_83818"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35488"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35703"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_90755"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78298"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50137"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_134688"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>PMID:24659754</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28029718</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28184294</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:7465</oboInOwl:id>
        <oboInOwl:hasDbXref>PMID:27700187</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28118565</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:16590-41-3</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Patent:US3332950</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28061017</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27922226</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Wikipedia:Naltrexone</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>KEGG:D05113</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28044452</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27787292</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>LINCS:LSM-3962</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27813192</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28153651</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Drug_Central:1765</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>DrugBank:DB00704</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasExactSynonym>3,14-dihydroxy-17-(cyclopropylmethyl)-4,5alpha-epoxymorphinan-6-one</oboInOwl:hasExactSynonym>
        <ns5:smiles>Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC1CC1</ns5:smiles>
        <oboInOwl:hasDbXref>PMID:28161142</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>N-Cyclopropylmethylnoroxymorphone</oboInOwl:hasRelatedSynonym>
        <ns5:inchi>InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1</ns5:inchi>
        <oboInOwl:hasDbXref>PMID:28106937</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28168894</oboInOwl:hasDbXref>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasDbXref>HMDB:HMDB0014842</oboInOwl:hasDbXref>
        <ns4:IAO_0000115>An  organic heteropentacyclic compound that is naloxone substituted in which the allyl group attached to the nitrogen is replaced by a cyclopropylmethyl group. A mu-opioid receptor antagonist, it is used to treat alcohol dependence.</ns4:IAO_0000115>
        <ns5:monoisotopicmass>341.16271</ns5:monoisotopicmass>
        <oboInOwl:hasRelatedSynonym>naltrexone</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>N-Cyclopropylmethyl-14-hydroxydihydromorphinone</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:C07253</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27690505</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28144772</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:28068780</oboInOwl:hasDbXref>
        <ns5:mass>341.40096</ns5:mass>
        <oboInOwl:hasDbXref>PMID:28011389</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Naltrexone</oboInOwl:hasExactSynonym>
        <ns5:inchikey>DQCKKXVULJGBQN-XFWGSAIBSA-N</ns5:inchikey>
        <oboInOwl:hasDbXref>PMID:27875802</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:27987236</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:28130024</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:27936293</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Reaxys:3596648</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:17023477</oboInOwl:hasDbXref>
        <ns5:formula>C20H23NO4</ns5:formula>
        <oboInOwl:hasDbXref>PMID:24107112</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Beilstein:3596648</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_78298 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78298">
        <rdfs:label>environmental contaminant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_83818 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_83818">
        <rdfs:label>morphinane-like compound</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_90755 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_90755">
        <rdfs:label>antidote to opioid poisoning</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



