<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/ECTO?iri=http://purl.obolibrary.org/obo/CHEBI_7476"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:ns5="http://purl.obolibrary.org/obo/chebi/"
     xmlns:chebi2="http://purl.obolibrary.org/obo/chebi#"
     xmlns:chebi="http://purl.obolibrary.org/obo/chebi#3"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/RO_0000087 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0000087">
        <rdfs:label xml:lang="en">has role</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_25384 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25384">
        <rdfs:label>monocarboxylic acid</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35475 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35475">
        <rdfs:label>non-steroidal anti-inflammatory drug</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35481 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35481">
        <rdfs:label>non-narcotic analgesic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35493 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35493">
        <rdfs:label>antipyretic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35703 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35703">
        <rdfs:label>xenobiotic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_35845 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_35845">
        <rdfs:label>gout suppressant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_48851 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_48851">
        <rdfs:label>methoxynaphthalene</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50629 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50629">
        <rdfs:label>cyclooxygenase 2 inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_50630 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_50630">
        <rdfs:label>cyclooxygenase 1 inhibitor</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_59527 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_59527">
        <rdfs:label>naproxen(1-)</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_7476 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_7476">
        <rdfs:label>naproxen</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25384"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_48851"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35845"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_59527"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35703"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_78298"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35481"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35493"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50629"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_50630"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_35475"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0000087"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/CHEBI_88188"/>
            </Restriction>
        </rdfs:subClassOf>
        <oboInOwl:hasDbXref>DrugBank:DB00788</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>CAS:22204-53-1</oboInOwl:hasDbXref>
        <ns5:formula>C14H14O3</ns5:formula>
        <oboInOwl:hasRelatedSynonym>(+)-2-(6-Methoxy-2-naphthyl)propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>naproxeno</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:18044350</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid</oboInOwl:hasRelatedSynonym>
        <ns4:IAO_0000115>A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation  and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.</ns4:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:24478225</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>naproxene</oboInOwl:hasRelatedSynonym>
        <ns5:inchikey>CMWTZPSULFXXJA-VIFPVBQESA-N</ns5:inchikey>
        <oboInOwl:hasDbXref>Patent:US4009197</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:7476</oboInOwl:id>
        <ns5:smiles>COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O</ns5:smiles>
        <oboInOwl:hasExactSynonym>Naproxen</oboInOwl:hasExactSynonym>
        <ns5:inchi>InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1</ns5:inchi>
        <ns5:charge>0</ns5:charge>
        <oboInOwl:hasDbXref>Wikipedia:Naproxen</oboInOwl:hasDbXref>
        <ns5:mass>230.25920</ns5:mass>
        <oboInOwl:hasRelatedSynonym>(+)-(S)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:9784154</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Patent:US3904682</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>naproxen</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>(S)-Naproxen</oboInOwl:hasRelatedSynonym>
        <ns5:monoisotopicmass>230.09429</ns5:monoisotopicmass>
        <oboInOwl:hasDbXref>HMDB:HMDB0001923</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(S)-2-(6-Methoxy-2-naphthyl)propanoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-2-(Methoxy-2-naphthyl)-propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasAlternativeId>CHEBI:603695</oboInOwl:hasAlternativeId>
        <oboInOwl:hasRelatedSynonym>(+)-2-(Methoxy-2-naphthyl)-propionsaeure</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(S)-(+)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>naproxenum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>LINCS:LSM-5689</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Drug_Central:1883</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(S)-2-(6-Methoxy-2-naphthyl)propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:D00118</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Beilstein:3591067</oboInOwl:hasDbXref>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi#3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_78298 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_78298">
        <rdfs:label>environmental contaminant</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_88188 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_88188">
        <rdfs:label>drug allergen</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



