has role hexahydronaphthalenes ferroptosis inducer geroprotector delta-lactone fatty acid ester lovastatin prodrug EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor statin (semi-synthetic) simvastatin RYMZZMVNJRMUDD-HGQWONQESA-N Simvastatin DrugBank:DB00641 Wikipedia:Simvastatin PMID:18199328 LINCS:LSM-2492 Simvastatine 0 PMID:17640385 InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 MK-733 PMID:14691614 PMID:22737247 PMID:14973129 HMDB:HMDB0005007 CHEBI:45577 C25H38O5 PMID:12827636 Simvastatina CHEBI:9150 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 PMID:18936176 Patent:EP33538 418.27192 A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. PMID:11336576 PMID:16144183 Drug_Central:2445 PMID:14561068 CAS:79902-63-9 Simvastatinum 418.56620 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one PMID:18688862 Beilstein:4768037 Zocor Patent:US4444784 KEGG:D00434 simvastatin chebi_ontology (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate