has role independent continuant nitrile pyrazoles sulfonamide hypoglycemic agent immunosuppressive agent antirheumatic drug pyrrolopyrimidine azetidines antipsoriatic neuroprotective agent anti-HIV agent ophthalmology drug anti-inflammatory agent EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor baricitinib A pyrrolopyrimidine that is 7<em>H</em>-pyrrolo[2,3-<em>d</em>]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1<em>H</em>-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis. CHEBI:95341