Experiment annotation format JSON ISA-Tab ISA-JSON Investigation Study Assay JSON Ontologies should be used. Any ontology is accepted, as long as it is correctly recorded. The ISA model consists of three core entities to capture experimental metadata: Investigation, Study, and Assay. All ISA-JSON content should fall under one Investigation JSON structure in a single JSON file. json 1.26 ISA-JSON stands for Investigation / Study / Assay (ISA) JavaScript Object Notation (JSON) format, and it is comprised of metadata describing observational or experimental scientific studies. ISA-JSON is the JSON serialisation of the Investigation / Study / Assay (ISA) Abstract Model, complementing ISA-Tab (edam:format_3687). It supports the metadata related to multimodality/multi-omics studies which employ a combination of data acquisition techniques. From ISA-JSON, a serialisation to RDF (JSON-LD) is possible when using a series of JSON context files.