Fold recognition Domain prediction Protein fold prediction Fold prediction beta12orEarlier Protein domain prediction Recognize (predict and identify) known protein structural domains or folds in protein sequence(s) which (typically) are not accompanied by any significant sequence similarity to know structures. Methods use some type of mapping between sequence and fold, for example secondary structure prediction and alignment, profile comparison, sequence properties, homologous sequence search, kernel machines etc. Domains and folds might be taken from SCOP or CATH. Protein fold recognition Protein structure analysis Protein sequence analysis Alignment Protein comparison Protein feature detection