SNP detection This includes functional SNPs for large-scale genotyping purposes, disease-associated non-synonymous SNPs etc. SNP discovery SNP calling Single nucleotide polymorphism detection Find single nucleotide polymorphisms (SNPs) - single nucleotide change in base positions - between sequences. Typically done for sequences from a high-throughput sequencing experiment that differ from a reference genome and which might, especially by reference to population frequency or functional data, indicate a polymorphism. beta12orEarlier Variant calling