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    <!-- http://edamontology.org/topic_0078 -->

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        <rdfs:label>Proteins</rdfs:label>
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    <!-- http://edamontology.org/topic_0203 -->

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        <rdfs:label>Gene expression</rdfs:label>
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    <!-- http://edamontology.org/topic_0749 -->

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        <rdfs:label>Transcription factors and regulatory sites</rdfs:label>
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        <oboInOwl:hasNarrowSynonym>CCAAT box</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>CpG islands</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>Transcription factors</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>-10 signals</oboInOwl:hasNarrowSynonym>
        <rdfs:comment>Transcription factor proteins either promote (as an activator) or block (as a repressor) the binding to DNA of RNA polymerase. Regulatory sites including transcription factor binding site as well as promoters, enhancers, silencers and boundary elements / insulators.</rdfs:comment>
        <ns3:created_in>beta12orEarlier</ns3:created_in>
        <oboInOwl:hasNarrowSynonym>Isochores</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasHumanReadableId>Transcription_factors_and_regulatory_sites</oboInOwl:hasHumanReadableId>
        <rdfs:comment>This includes CpG rich regions (isochores) in a nucleotide sequence.</rdfs:comment>
        <oboInOwl:hasNarrowSynonym>Transcriptional regulatory sites</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>Terminators</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>CAAT signals</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>Attenuators</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasDefinition>Proteins that bind to DNA and control transcription of DNA to mRNA (transcription factors) and also transcriptional regulatory sites, elements and regions (such as promoters, enhancers, silencers and boundary elements / insulators) in nucleotide sequences.</oboInOwl:hasDefinition>
        <oboInOwl:hasNarrowSynonym>Enhancers</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>CAT box</oboInOwl:hasNarrowSynonym>
        <rdfs:comment>This includes promoters, CAAT signals, TATA signals, -35 signals, -10 signals, GC signals, primer binding sites for initiation of transcription or reverse transcription, enhancer, attenuator, terminators and ribosome binding sites.</rdfs:comment>
        <oboInOwl:hasNarrowSynonym>TATA signals</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>Promoters</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>GC signals</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>-35 signals</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>TFBS</oboInOwl:hasNarrowSynonym>
        <oboInOwl:hasNarrowSynonym>Transcription factor binding sites</oboInOwl:hasNarrowSynonym>
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    <!-- http://edamontology.org/topic_3125 -->

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        <rdfs:label>DNA binding sites</rdfs:label>
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