efavirenz 0 315.02739 315.678 reaxys:7387333 C14H9ClF3NO2 lincs.smallmolecule:LSM-5526 (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1 kegg.drug:D00896 kegg.compound:C08088 pubmed:25017682 drugbank:DB00625 CHEBI:119486 patent:EP582455 Efavirenz cas:154598-52-4 CHEBI:4760 wikipedia.en:Efavirenz CHEBI:190461 chebi_ontology (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one drugcentral:989 1,4-Dihydro-2<em>H</em>-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (<i>S</i> configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. patent:US5519021 pdb-ccd:EFZ XPOQHMRABVBWPR-ZDUSSCGKSA-N hmdb:HMDB0014763 (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE pubmed:10673109 pubmed:10576692 CHEBI:47396 O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one organic heterocyclic compound