<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/EFO?iri=http://purl.obolibrary.org/obo/CHEBI_15367"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="https://w3id.org/chemrof/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/"
     xmlns:ns3="http://purl.obolibrary.org/obo/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="https://w3id.org/chemrof/inchi_key_string"/>
    <AnnotationProperty rdf:about="https://w3id.org/chemrof/smiles_string"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="https://w3id.org/chemrof/charge"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="https://w3id.org/chemrof/generalized_empirical_formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="https://w3id.org/chemrof/mass"/>
    <AnnotationProperty rdf:about="https://w3id.org/chemrof/inchi_string"/>
    <AnnotationProperty rdf:about="https://w3id.org/chemrof/monoisotopic_mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_12777 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_12777">
        <rdfs:label>vitamin A</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_15367 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_15367">
        <rdfs:label>all-trans-retinoic acid</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_12777"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26536"/>
        <ns4:charge rdf:datatype="http://www.w3.org/2001/XMLSchema#integer">0</ns4:charge>
        <ns4:monoisotopic_mass rdf:datatype="http://www.w3.org/2001/XMLSchema#decimal">300.20893</ns4:monoisotopic_mass>
        <ns4:mass rdf:datatype="http://www.w3.org/2001/XMLSchema#decimal">300.442</ns4:mass>
        <oboInOwl:hasDbXref>pubmed:18162363</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:22532966</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18440196</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11343416</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:19587328</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11896294</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>wikipedia.en:Retinoic_acid</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:19427305</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasExactSynonym>(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid</oboInOwl:hasExactSynonym>
        <oboInOwl:hasDbXref>pubmed:22534100</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>wikipedia.en:Tretinoin</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:22134377</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11904404</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:16720557</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:7501014</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Acide retinoique (French)</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:34050114</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>all-trans-tretinoin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:33820492</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:14605492</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:14627725</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:14978018</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11214352</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>all-trans-retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>beta-Retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:16819260</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:17166212</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15476854</oboInOwl:hasDbXref>
        <ns4:inchi_key_string>SHGAZHPCJJPHSC-YCNIQYBTSA-N</ns4:inchi_key_string>
        <oboInOwl:hasDbXref>pubmed:22538278</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Atralin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:19597529</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11437362</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15376324</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>kegg.drug:D00094</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>reaxys:2057223</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:21993673</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:10970886</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:7704533</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15359008</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>all-trans-beta-Retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:12958591</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18318655</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:29492455</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15327395</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>trans-retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Tri-luma</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:17073551</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:17204142</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>vitamin A acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:22428994</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:22741806</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Ro 1-5488</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:15537748</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15675886</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18819820</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:16920920</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:16847436</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18183617</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2E,4E,6E,8E-tetraenoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:11073974</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>all-(E)-retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:18977311</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>all-trans-vitamin A1 acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:22261335</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:19814868</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Retisol-A</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:18800767</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:16688769</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pdb-ccd:REA</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Veltin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Dermairol</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasAlternativeId>CHEBI:45376</oboInOwl:hasAlternativeId>
        <oboInOwl:hasRelatedSynonym>Biacna</oboInOwl:hasRelatedSynonym>
        <ns3:IAO_0000115>A retinoic acid in which all four exocyclic double bonds have &lt;i&gt;E&lt;/i&gt;- (&lt;i&gt;trans&lt;/i&gt;-) geometry.</ns3:IAO_0000115>
        <oboInOwl:hasRelatedSynonym>Refissa</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasAlternativeId>CHEBI:8815</oboInOwl:hasAlternativeId>
        <oboInOwl:hasDbXref>pubmed:22180426</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>all-trans retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>AGN 100335</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:16685080</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:19112091</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11332619</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:17447762</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:14581379</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:19841174</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>all-trans-vitamin A acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>drugbank:DB00755</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Cordes vas</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>Avita</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:34091189</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18404486</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:14705145</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:14704332</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Renova</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>hmdb:HMDB0001852</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>tretinoina</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>foodb.food:FDB022710</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:19144697</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18400206</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>tretinoinum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>tretinoine</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>retinoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:11722649</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:21924320</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Stieva-A</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:15318809</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:22244299</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Vesanoid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:21898109</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18052213</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:33662750</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>cas:302-79-4</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15194426</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Betarretin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:10022884</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18085670</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Altreno</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:34050360</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>drugcentral:2722</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:11556813</oboInOwl:hasDbXref>
        <ns4:inchi_string>InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+</ns4:inchi_string>
        <oboInOwl:hasDbXref>pubmed:18322276</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:18678272</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:15367</oboInOwl:id>
        <ns4:smiles_string>CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1</ns4:smiles_string>
        <oboInOwl:hasDbXref>pubmed:7961949</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:27759097</oboInOwl:hasDbXref>
        <ns4:generalized_empirical_formula>C20H28O2</ns4:generalized_empirical_formula>
        <oboInOwl:hasDbXref>pubmed:16569247</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:22514600</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:19018099</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:22177959</oboInOwl:hasDbXref>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>Tretin M</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>kegg.compound:C00777</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>Retin-A</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>pubmed:15539337</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>pubmed:15839997</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>lipidmaps:LMPR01090019</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>tretinoin</oboInOwl:hasRelatedSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/chebi/3_STAR"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_26536 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_26536">
        <rdfs:label>retinoic acid</rdfs:label>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



