has_role isoprenoid aphidicolin 0 338.24571 338.488 pubmed:22302683 CHEBI:2766 CiteXplore:21917855 pubmed:33592314 CiteXplore:22339690 pubmed:1483268 A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[<em>a</em>]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. CiteXplore:22210918 pubmed:25948499 pubmed:10592317 chebi_ontology pubmed:23221037 pubmed:21212237 (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol knapsack:C00000873 ChemIDplus:38966-21-1 NOFOAYPPHIUXJR-APNQCZIXSA-N InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 beilstein:4689958 (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol lincs.smallmolecule:LSM-45486 ChemIDplus:4689958 kegg.compound:C06088 CiteXplore:21212237 KEGG COMPOUND:38966-21-1 pubmed:22339690 pubmed:27265376 pubmed:19735659 KEGG COMPOUND:C06088 CiteXplore:21444690 C20H34O4 CiteXplore:21708134 pubmed:31712575 pubmed:29191129 cas:38966-21-1 pubmed:21897020 pubmed:27223263 ChEMBL:139198 pubmed:22293751 pubmed:22262459 pdb-ccd:2ZE pubmed:33721476 pubmed:22365495 Reaxys:2055641 patent:US3761512 MESH:D016590 CiteXplore:22139884 CiteXplore:21897020 pubmed:31448675 pubmed:21444690 CiteXplore:19735659 pubmed:26854444 pubmed:7478586 pubmed:26255574 [H][C@@]12CC[C@]3([H])[C@](C)(CC[C@@H](O)[C@@]3(C)CO)[C@]13CC[C@](O)(CO)[C@H](C2)C3 pubmed:24492257 pubmed:21812410 pubmed:31403790 reaxys:2055641 CiteXplore:21812410 metacyc.compound:CPD-11426 Aphidicolin pubmed:22139884 chemspider:10280269 pubmed:25429975 pubmed:22210918 pubmed:21917855 wikipedia.en:Aphidicolin CiteXplore:22302683 (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol CiteXplore:22293751 CiteXplore:22365495 aphidocolin pubmed:32394671 CiteXplore:22262459 pubmed:21708134 antimicrobial agent