has_role peptide thiostrepton 0 1663.49235 1664.922 bryamycin CiteXplore:21903609 vsdb:3007 pubmed:22108865 pubmed:22353937 pubmed:37662481 pubmed:22271891 pubmed:37646656 pubmed:21860463 pubmed:38634704 pubmed:37752225 metacyc.compound:CPD-13481 SNOMEDCT:96017003 pubmed:36152915 pubmed:33193851 pubmed:33498547 pubmed:34863996 pubmed:21107477 cas:1393-48-2 CiteXplore:22353937 [H][C@]12N=C(c3nc(C(=O)NC(=C)C(=O)NC(=C)C(N)=O)cs3)CC[C@@]13NC(=O)[C@H](C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@H]([C@@H](C)CC)N[C@@H]1C=Cc4c([C@H](C)O)cc(nc4[C@H]1O)C(=O)O[C@H](C)[C@H](NC(=O)c1csc(n1)[C@H]([C@](C)(O)[C@@H](C)O)NC(=O)[C@H]1CSC(=N1)/C(=C/C)NC(=O)[C@H]([C@@H](C)O)NC(=O)c1csc3n1)c1nc2cs1 pubmed:34369229 CiteXplore:22108865 ChemIDplus:1393-48-2 pubmed:33515584 KEGG DRUG:D06111 knapsack:C00000753 pubmed:21620902 chebi_ontology reaxys:7390758 gargon MESH:D013883 CiteXplore:22391527 pubmed:36910221 pubmed:22321511 C72H85N19O18S5 pubmed:21908407 CiteXplore:21323347 pubmed:21323347 CiteXplore:22049175 pubmed:35859150 pubmed:14405296 drugbank:DB11467 CiteXplore:21620902 kegg.drug:D06111 KEGG COMPOUND:1393-48-2 pubmed:36097108 wikipedia.en:Thiostrepton CiteXplore:16076225 pubmed:16076225 pubmed:32330398 pubmed:22357874 CiteXplore:21365012 CiteXplore:21107477 Reaxys:7390758 CHEBI:29693 KEGG COMPOUND:C12054 pubmed:22049175 InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13,108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17,20-22,24-26,30-35,39,45,47-49,51-53,79,92-95,108H,4-6,14,18-19,23H2,1-3,7-13H3,(H2,73,96)(H,74,97)(H,75,99)(H,76,98)(H,77,101)(H,78,105)(H,82,106)(H,88,103)(H,89,102)(H,90,104)(H,91,100)/b38-15-/t26-,30-,31-,32-,33+,34+,35+,39+,45+,47-,48-,49-,51-,52+,53+,71+,72+/m0/s1 pubmed:21903609 pubmed:35873171 CiteXplore:22271891 pubmed:21365012 Thiostrepton CiteXplore:21908407 NSFFHOGKXHRQEW-AIHSUZKVSA-N pubmed:22391527 CiteXplore:22357874 thiostrepton A thiactin pubmed:31835481 CiteXplore:22321511 A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitumor agent. pubmed:19652535 CiteXplore:21860463 pubmed:38652969 kegg.compound:C12054 antibacterial drug