has_role chemical entity nemonapride 0 387.17135 387.91 CiteXplore:9325557 MESH:C030265 ChemIDplus:75272-39-8 pubmed:10917400 CHEBI:31899 pubmed:9310388 CiteXplore:9310388 Emilace drugcentral:1895 wikipedia.en:Nemonapride kegg.compound:C12915 pubmed:9325557 Reaxys:5766104 patent:EP1273301 pubmed:10898926 nemonapride pubmed:8328325 KEGG DRUG:D01468 CiteXplore:9774248 (+-)-cis-N-(1-benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-methylaminobenzamide CiteXplore:9369342 pubmed:9016292 CiteXplore:10363800 CiteXplore:9766869 CiteXplore:10435376 pubmed:9934942 KEGG COMPOUND:75272-39-8 CiteXplore:10587100 pubmed:10862524 reaxys:5766104 CiteXplore:11817505 YM 09151-2 pubmed:9095318 nemonaprida CiteXplore:10049714 C21H26ClN3O2 nemonapridum kegg.drug:D01468 CiteXplore:16020947 CiteXplore:11929700 racemic nemonapride rac-N-[(2S,3S)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide pubmed:11929700 patent:US5811547 rac-nemonapride pubmed:16020947 pubmed:10363800 YM-09151 emonapride cas:75272-39-8 chebi_ontology pubmed:9228185 pubmed:10823405 KEGG COMPOUND:C12915 (+-)-cis-N-(1-benzyl-2-methyl-3-pyrrolidinyl)-5-chloro-4-(methylamino)-o-anisamide pubmed:9774248 pubmed:9369342 CiteXplore:10898926 CiteXplore:9228185 CiteXplore:10823405 pubmed:9766869 pubmed:9031995 pubmed:10049714 pubmed:11817505 NCIt:C73036 pubmed:10587100 CiteXplore:9095318 rac-N-[(2S,3S)-1-benzyl-2-methylpyrrolidin-3-yl]-5-chloro-2-methoxy-4-(methylamino)benzamide (+-)-nemonapride A racemate composed of (2<i>S</i>,3<i>S</i>)- and (2<i>R</i>,3<i>R</i>)-enantiomers of nemonapride. Highly potent dopamine D<small>₂</small>-like receptor antagonist; selective over D<small>₁</small>-like receptors (Ki values are 0.1 and 740 nM for D<small>₂</small>-like and D<small>₁</small>-like receptors respectively). Also potent 5-HT<small>_1A</small> receptor agonist (IC<small>₅₀</small> = 34 nM) and has affinity for sigma receptors. CiteXplore:10917400 pubmed:10435376 CiteXplore:10862524 CiteXplore:9934942 drug role