organic heterocyclic compound abacavir 0 286.15421 286.339 A 2,6-diaminopurine that is (1<i>S</i>)-cyclopent-2-en-1-ylmethanol in which the <em>pro</em>-<i>R</i> hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9<em>H</em>-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection. pubmed:11678376 pubmed:15887959 pubmed:11806176 reaxys:7493116 {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol drugcentral:34 ABC kegg.compound:C07624 pubmed:26024233 CHEBI:441792 pubmed:16539393 cas:136470-78-5 chebi_ontology pubmed:17172311 beilstein:7493116 pubmed:24751900 CHEBI:520984 pubmed:17870541 pubmed:18029175 CHEBI:525912 MCGSCOLBFJQGHM-SCZZXKLOSA-N {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol CHEBI:421707 CHEBI:2360 pubmed:16458506 Abacavir InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1 kegg.drug:D07057 pubmed:16759112 pubmed:25674793 abacavir CHEBI:193608 wikipedia.en:Abacavir C14H18N6O pubmed:18549801 pubmed:25017682 pubmed:12781181 drugbank:DB01048 Nc1nc(NC2CC2)c2ncn([C@H]3C=C[C@@H](CO)C3)c2n1