has_role chemical entity antineoplastic agent (-)-demecolcine 0 371.17327 371.433 (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one Reaxys:2822892 N-deacetyl-N-methylcolchicine ChEMBL:238150 knapsack:C00027138 Santavy's substance F MESH:D003703 CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(OC)c(=O)cc21 demecolcinum chebi_ontology pubmed:22394737 pubmed:7887202 CiteXplore:22394737 CiteXplore:20082301 pubmed:20082301 A secondary amino compound that is (<i>S</i>)-colchicine in which the <em>N</em>-acetyl group is replaced by an <em>N</em>-methyl group. Isolable from the autumn crocus, <em>Colchicum autumnale</em>, it is less toxic than colchicine and is used as an antineoplastic. Reichstein's F Colcemid N-methyl-N-deacetylcolchicine InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1 NNJPGOLRFBJNIW-HNNXBMFYSA-N CiteXplore:2329167 C21H25NO5 pubmed:1061646 CiteXplore:2977921 NCIt:C419 reaxys:2822892 pubmed:7720099 (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one lincs.smallmolecule:LSM-6590 CiteXplore:7720099 ChemIDplus:477-30-5 pubmed:7237451 cas:477-30-5 patent:DE936268 N-methyl-N-desacetylcolchicine CiteXplore:7237451 KEGG COMPOUND:477-30-5 wikipedia.en:Demecolcine N-desacetyl-N-methylcolchicine (-)-colchamine demecolcine pubmed:2329167 CiteXplore:7887202 demecolcina CHEBI:4393 CiteXplore:1061646 drugcentral:4375 pubmed:2977921 kegg.compound:C11250 KEGG COMPOUND:C11250