has_role organic heterocyclic compound carboxylic acid antineoplastic agent antirheumatic drug carboxamide methotrexate 0 454.17132 454.447 NCIt:C642 kegg.compound:C01937 Methotrexate N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid wikipedia.en:Methotrexate methotrexatum InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1 SNOMEDCT:68887009 drugbank:DB00563 SNOMEDCT:387381009 4-amino-10-methylfolic acid chebi_ontology METHOTREXATE Emtexate drugcentral:1751 N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1 CHEBI:44183 C20H22N8O5 Rheumatrex CHEBI:44185 Trexall Ledertrexate metotrexato pdb-ccd:MTX CHEBI:6837 methotrexate lincs.smallmolecule:LSM-5690 MESH:D008727 FBOZXECLQNJBKD-ZDUSSCGKSA-N cas:59-05-2 4-amino-N(10)-methylpteroylglutamic acid MTX beilstein:70669 kegg.drug:D00142 patent:US2512572 EC 1.5.1.3 (dihydrofolate reductase) inhibitor