has_role chemical entity antimetabolite antineoplastic agent immunosuppressive agent 5-fluorouracil 0 130.01786 130.078 5-fluorouracil 5-FU lincs.smallmolecule:LSM-4261 pubmed:12520460 5-fluoropyrimidine-2,4(1H,3H)-dione SNOMEDCT:3127006 hmdb:HMDB0014684 pdb-ccd:URF CHEBI:2054 C4H3FN2O2 fluorouracil O=c1ncc(F)c(=O)n1 ChemIDplus:51-21-8 5-Fluorouracil Fluorouracil 5-fluoropyrimidine-2,4(1H,3H)-dione pubmed:14769231 drugbank:DB00544 ChEMBL:468538 KEGG COMPOUND:51-21-8 wikipedia.en:Fluorouracil KEGG COMPOUND:C07649 kegg.compound:C07649 chebi_ontology 5-Fluorouracil MESH:D005472 GHASVSINZRGABV-UHFFFAOYSA-N SNOMEDCT:387172005 pubmed:19023200 5-Fluoracil CHEBI:46343 beilstein:127172 A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. drugcentral:26 kegg.drug:D00584 InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) pubmed:11356943 cas:51-21-8 5-fluorouracil CHEBI:46345 NCIt:C505 reaxys:127172 fluorouracilum Beilstein:127172 5-Fluoropyrimidine-2,4-dione fluorouracilo