has_role organic heterocyclic compound antineoplastic agent carboxamide dasatinib (anhydrous) 0 487.15572 488.017 CHEBI:49375 N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE pubmed:19502192 anhydrous dasatinib pubmed:22411867 pdb-ccd:1N1 C22H26ClN7O2S drugbank:DB01254 BMS-354825 dasatinib NCIt:C38713 SNOMEDCT:423658008 N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE pubmed:18784745 pubmed:18823558 pubmed:22992064 anh. dasatinib kegg.drug:D03658 patent:WO2010067374 pubmed:23065516 ZBNZXTGUTAYRHI-UHFFFAOYSA-N An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). pubmed:17154512 pubmed:18797457 pubmed:16775234 pubmed:18020922 CHEBI:38943 SNOMEDCT:422756008 BMS Dasatinib patent:US7941725 dasatinibum InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) pubmed:21226671 hmdb:HMDB0015384 patent:WO2010139979 chebi_ontology pubmed:22740998 wikipedia.en:Dasatinib N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide MESH:C488369 Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 patent:US7125875 drugcentral:785 lincs.smallmolecule:LSM-1020 pubmed:19640584 dasatinib (anh.) pubmed:19494352 N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide cas:302962-49-8 reaxys:9966762 CHEBI:49372