organic heterocyclic compound vandetanib 0 474.10667 475.362 pubmed:22184381 pubmed:22500115 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) pubmed:16377413 pubmed:15604279 pubmed:19622715 pubmed:16179094 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine pubmed:17409986 pubmed:20371720 pubmed:22667325 pubmed:19394692 pubmed:16688779 pubmed:17878479 patent:US2008199480 pubmed:17393165 wikipedia.en:Vandetanib pubmed:22158569 pubmed:22075979 A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. pubmed:22505191 pubmed:19088171 UHTHHESEBZOYNR-UHFFFAOYSA-N cas:443913-73-3 vandetanib pubmed:22169262 patent:US2006135486 chebi_ontology pubmed:16783964 pubmed:15367698 pubmed:22307735 CHEBI:38942 patent:WO2008007113 pubmed:22938056 pubmed:22781612 reaxys:9161676 pubmed:18698025 pubmed:19946413 CHEBI:49959 patent:WO2007036713 C22H24BrFN4O2 pubmed:22346266 pubmed:22343387 pubmed:21046425 pubmed:12684431 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 pubmed:19332730 pubmed:17136225 kegg.drug:D06407 pubmed:17631646 pubmed:16140331 pubmed:21353546 pubmed:14760102 ZD6474 pubmed:22665903 pubmed:15623642 pubmed:18936474 pubmed:22633931 patent:US2008032989 pubmed:15928657 Zactima pubmed:19881951 pubmed:16299247 drugcentral:4178 pubmed:19211364 pubmed:16843002 pubmed:16361567 drugbank:DB08764 patent:WO2005115145 pubmed:15623658 pubmed:17912240 pubmed:22898678 pubmed:18228115 pubmed:22608542 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine pubmed:19349511 pubmed:22370318 pubmed:19883226 pubmed:15305185 lincs.smallmolecule:LSM-1199 pubmed:19220256 patent:WO2009024825 pubmed:22245891 patent:WO2006005915 pdb-ccd:ZD6 pubmed:22611027 pubmed:19687425 pubmed:15596048 ZD 6474 patent:WO2008001101 patent:WO2012055015 pubmed:19512898 CHEBI:49960 pubmed:22830347 pubmed:22701615 pubmed:21718364 4-BROMO-2-FLUORO-N-[(4E)-6-METHOXY-7-[(1-METHYLPIPERIDIN-4-YL)METHOXY]QUINAZOLIN-4(1H)-YLIDENE]ANILINE pubmed:19002384