has_role
organic heterocyclic compound
antineoplastic agent
carboxamide
bortezomib
0
384.19689
384.245
PS-341
drugcentral:391
reaxys:8723817
N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
drugbank:DB00188
pubmed:21504411
[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
GXJABQQUPOEUTA-RDJZCZTQSA-N
C19H25BN4O4
cas:179324-69-7
wikipedia.en:Bortezomib
NCIt:C1851
CHEBI:52717
pubmed:18484921
CHEBI:41143
pdb-ccd:BO2
MESH:C400082
InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
SNOMEDCT:398907002
lincs.smallmolecule:LSM-6281
pubmed:21865767
kegg.drug:D03150
<small>L</small>-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at <em>N</em><small><sup>α</small></sup> by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
PS 341
pubmed:18980173
N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
Velcade
chebi_ontology
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O
bortezomib
SNOMEDCT:407097007
[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid