has_role antiviral agent organic heterocyclic compound phosphate antimetabolite antineoplastic agent immunosuppressive agent prodrug fludarabine phosphate 0 365.05366 365.214 pubmed:20467451 CHEBI:31616 SNOMEDCT:108765002 pubmed:21909959 pubmed:19567212 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine pubmed:21296675 InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1 FAMP drugcentral:1189 CiteXplore:20467451 "PubMed citation" Fludarabine 5'-monophosphate CiteXplore:21736869 "PubMed citation" CiteXplore:21725721 "PubMed citation" cas:75607-67-9 CiteXplore:19915381 "PubMed citation" wikipedia.en:Fludarabine Wikipedia:Fludarabine "Wikipedia" pubmed:21725721 CiteXplore:21909959 "PubMed citation" 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate CHEBI:63599 pubmed:8528057 2-Fluoro-ARA AMP pubmed:19283354 CiteXplore:19283354 "PubMed citation" patent:WO2010046917 CiteXplore:20686506 "PubMed citation" 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate) pubmed:20686506 A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. CiteXplore:21296675 "PubMed citation" chebi_ontology 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate drugbank:DB01073 CiteXplore:19567212 "PubMed citation" pubmed:20215092 pubmed:21736869 Fludara 2-Fluoroadenine arabinoside 5'-monophosphate 2F-ara-AMP Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O pubmed:20514405 reaxys:8167686 pubmed:8651523 CiteXplore:20215092 "PubMed citation" DrugBank:DB01073 "DrugBank" CiteXplore:20514405 "PubMed citation" KEGG DRUG:75607-67-9 "CAS Registry Number" NCIt:C1102 Patent:WO2010133629 "Patent" pubmed:10720130 patent:WO2010133629 GIUYCYHIANZCFB-FJFJXFQQSA-N pubmed:19915381 Fludarabine monophosphate kegg.drug:D01907 pubmed:19862681 CiteXplore:19862681 "PubMed citation" pubmed:8204523 KEGG DRUG:D01907 "KEGG DRUG" ChemIDplus:75607-67-9 "CAS Registry Number" C10H13FN5O7P Patent:WO2010046917 "Patent" Reaxys:8167686 "Reaxys Registry Number" MESH:C042382 ionic salt