fatty acid pravastatin 0 424.2461 424.534 chebi_ontology TUZYXOIXSAXUGO-PZAWKZKUSA-N CHEBI:63618 reaxys:4825538 (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid hmdb:HMDB0005022 pravastatin pravastatina drugcentral:2239 pravastatine drugbank:DB00175 CHEBI:8360 wikipedia.en:Pravastatin cas:81093-37-0 InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1 kegg.drug:D08410 [H][C@@]12C(=C[C@@H](O)C[C@@H]1OC(=O)[C@@H](C)CC)C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(=O)O lincs.smallmolecule:LSM-3347 pubmed:21749370 (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid pravastatinum pravastatin acid (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid C23H36O7 pubmed:25264019 kegg.compound:C01844 pubmed:21851379 knapsack:C00000565 A carboxylic ester resulting from the formal condensation of (<i>S</i>)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3<i>R</i>,5<i>R</i>)-7-[(1<i>S</i>,2<i>S</i>,6<i>S</i>,8<i>S</i>,8a<i>R</i>)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.