has_role organic heterocyclic compound antineoplastic agent EC 5.99.1.2 (DNA topoisomerase) inhibitor topotecan 0 421.16377 421.453 DrugBank:DB01030 "DrugBank" KEGG DRUG:D08618 "KEGG DRUG" CiteXplore:22028494 "PubMed citation" SNOMEDCT:372536007 CiteXplore:22190039 "PubMed citation" topotecane CiteXplore:21255983 "PubMed citation" KEGG COMPOUND:C11158 "KEGG COMPOUND" CiteXplore:20574789 "PubMed citation" InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 topotecan pubmed:22136714 Reaxys:4279441 "Reaxys Registry Number" SNOMEDCT:108779005 Patent:EP321122 "Patent" patent:EP321122 reaxys:4279441 CHEBI:63632 drugbank:DB01030 pubmed:22028494 cas:123948-87-8 pubmed:21910214 A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. kegg.compound:C11158 lincs.smallmolecule:LSM-5662 KEGG COMPOUND:123948-87-8 "CAS Registry Number" NCIt:C1413 pubmed:21352915 pubmed:22075006 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin topotecanum chebi_ontology Wikipedia:Topotecan "Wikipedia" CiteXplore:21352915 "PubMed citation" CHEBI:9634 ChemIDplus:123948-87-8 "CAS Registry Number" pubmed:22190039 CiteXplore:22136714 "PubMed citation" (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Topotecan pubmed:21255983 MESH:D019772 wikipedia.en:Topotecan kegg.drug:D08618 pdb-ccd:TTC CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1 UCFGDBYHRUNTLO-QHCPKHFHSA-N pubmed:20574789 (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione CiteXplore:21910214 "PubMed citation" CiteXplore:22075006 "PubMed citation" C23H23N3O5