SB 224289 hydrochloride
0
556.22412
557.094
1'-methyl-5-{[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl}-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidinium] chloride
(1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride
InChI=1S/C32H32N4O3.ClH/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32;/h4-9,16-18H,10-15,19H2,1-3H3;1H
pubmed:20306273
reaxys:8248456
Reaxys:8248456
CHEBI:64067
(1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidin]-5-yl)[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride
GKGKBZYMDILCOF-UHFFFAOYSA-N
C32H32N4O3.HCl
Cc1nc(-c2ccc(-c3ccc(C(=O)N4CCc5cc6c(cc54)C4(CCN(C)CC4)CO6)cc3)c(C)c2)no1.Cl
A hydrochloride that is the monohydrochloride salt of SB 224289. Selective 5-HT<small><sub>1B</sub></small> receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT<small><sub>1D</sub></small>, 5-HT<small><sub>1A</sub></small>, 5-HT<small><sub>1E</sub></small>, 5-HT<small><sub>1F</sub></small>, 5-HT<small><sub>2A</sub></small> and 5-HT<small><sub>2C</sub></small> receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo.
1'-methyl-5-{[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl}-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidinium] chloride
chebi_ontology
ChEMBL:805862
CiteXplore:20306273
ionic salt