vanoxerine dihydrochloride 0 522.20163 523.495 ChemIDplus:67469-78-7 MIBSKSYCRFWIRU-UHFFFAOYSA-N CiteXplore:7700571 pubmed:10939577 pubmed:7700571 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride ChEMBL:646658 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine dihydrochloride 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazinediium dichloride pubmed:10640288 Reaxys:5696321 Cl.Cl.Fc1ccc(C(OCCN2CCN(CCCc3ccccc3)CC2)c2ccc(F)cc2)cc1 GBR12909 dihydrochloride CiteXplore:8884229 GBR 12909 dihydrochloride A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC<small>₅₀</small> = 48 nM). Centrally active following systemic administration. CiteXplore:10640288 pubmed:8884229 CiteXplore:10939577 chebi_ontology reaxys:5696321 C28H32F2N2O.2HCl Vanoxerine hydrochloride InChI=1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H CiteXplore:16014753 cas:67469-78-7 pubmed:16014753 CHEBI:64086 ionic salt