4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride 0 443.17758 443.95 S 14506 COc1ccc2cccc(N3CCN(CCNC(=O)c4ccc(F)cc4)CC3)c2c1.Cl C24H26FN3O2.HCl MESH:C092824 CiteXplore:7698199 1-((4-Fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride Reaxys:8374093 HWLZKPKZVOLFGK-UHFFFAOYSA-N S 14506 monohydrochloride reaxys:8374093 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride cas:135721-98-1 A hydrochloride salt that is obtained by reaction of 4-fluoro-<em>N</em>-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide with one equivalent of hydrogen chloride. Highly potent selective 5-HT<small>_1A</small> receptor full agonist (pKi values are 9.0, 6.6, 7.5, 6.6 and < 6.0 for 5-HT<small>_1A</small>, 5-HT<small>_1B</small>, 5-HT<small>_1C</small>, 5-HT<small>₂</small> and 5-HT<small>₃</small> receptors respectively). Possibly binds between the agonist binding site and the G protein interaction switch site, affecting the activation mechanism, and may display positive cooperativity. Anxiolytic following central administration in vivo. S-14506 InChI=1S/C24H26FN3O2.ClH/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19;/h2-10,17H,11-16H2,1H3,(H,26,29);1H S14506 hydrochloride ChemIDplus:135721-98-1 CHEBI:64099 pubmed:7698199 S14506 monohydrochloride S 14506 hydrochloride chebi_ontology 4-fluoro-N-{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl}benzamide hydrochloride ionic salt