organic heterocyclic compound phenols 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol 0 386.16304 386.451 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)triphenol CHEBI:64110 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)triphenol chebi_ontology A pyrazole that is 1<em>H</em>-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC<small>₅₀</small> ~ 200 pM); displays 410-fold selectivity for ERα over ERβ. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. C24H22N2O3 InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3 1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole reaxys:8798122 CCCc1c(-c2ccc(O)cc2)nn(-c2ccc(O)cc2)c1-c1ccc(O)cc1 IOTXSIGGFRQYKW-UHFFFAOYSA-N