GR 127935 hydrochloride 0 533.21937 534.06 N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride GR127935 hydrochloride Reaxys:8530522 4-[2-methoxy-5-({[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl}amino)phenyl]-1-methylpiperazin-1-ium chloride A hydrochloride obtained by reaction of GR 127935 with one equivalent of hydrochloric acid. Potent and selective 5-HT<small>_1B/1D</small> receptor antagonist (pKi values are 8.5 for both guinea pig 5-HT<small>_1D</small> and rat 5-HT<small>_1B</small> receptors). Displays > 100-fold selectivity over 5HT<small>_1A</small>, 5-HT<small>_2A</small>, 5-HT<small>_2C</small> receptors and other receptor types. Centrally active following oral administration. COc1ccc(NC(=O)c2ccc(-c3ccc(-c4noc(C)n4)cc3C)cc2)cc1N1CCN(C)CC1.Cl chebi_ontology InChI=1S/C29H31N5O3.ClH/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34;/h5-12,17-18H,13-16H2,1-4H3,(H,31,35);1H SRVVUYIJVBLEJI-UHFFFAOYSA-N ChEMBL:805646 C29H31N5O3.HCl reaxys:8530522 N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxamide hydrochloride CHEBI:64111 ionic salt