has_role organic heterocyclic compound antineoplastic agent carboxamide tanespimycin 0 585.30502 585.698 17-allylaminogeldanamycin CiteXplore:21791475 NCIt:C37899 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate pubmed:21219297 CHEBI:64153 pubmed:21594721 17-AAG 17-N-allylamino-17-demethoxygeldanamycin CiteXplore:21534941 kegg.drug:D06650 AYUNIORJHRXIBJ-TXHRRWQRSA-N CiteXplore:21856392 CiteXplore:20652703 pubmed:22047770 CiteXplore:22047770 CiteXplore:21594721 pubmed:25096912 C=CCNC1=C2C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)[C@H](OC(N)=O)[C@@H](OC)/C=CC=C(/C)C(=O)NC(=CC1=O)C2=O pubmed:25633180 CiteXplore:21558407 pubmed:22377218 17-(Allylamino)geldanamycin pubmed:25952464 CiteXplore:21283735 ChemIDplus:75747-14-7 pubmed:20652703 reaxys:7402240 CiteXplore:21219297 ChEMBL:283934 cas:75747-14-7 CiteXplore:20683637 CiteXplore:21454186 pubmed:21558407 17-(Allylamino)-17-demethoxygeldanamycin tanespimycine tanespimycina pubmed:26277605 CiteXplore:22209975 pubmed:21856392 MESH:C112765 17-demethoxy-17-(2-propenylamino)geldanamycin chebi_ontology (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate CiteXplore:21670086 pubmed:26913406 17AAG pubmed:23564374 pubmed:21791475 pubmed:22621282 pubmed:21454186 NSC 330507 pubmed:22209975 pubmed:20683637 Reaxys:7402240 pubmed:21534941 pubmed:21670086 pubmed:20646760 pubmed:27045471 pubmed:26872308 pubmed:24317439 pubmed:21283735 tanespimycinum tanespimycin A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects. 17-Demethoxy-17-allylamino geldanamycin pubmed:26408708 pubmed:26922527 NSC-330507 InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1 C31H43N3O8 CiteXplore:22377218 wikipedia.en:17-N-Allylamino-17-demethoxygeldanamycin