has_role
organic heterocyclic compound
serotonergic antagonist
dopaminergic antagonist
ritanserin
0
477.16864
477.58
CiteXplore:11897543
A thiazolopyrimidine that is 5<em>H</em>-[1,3]thiazolo[3,2-<em>a</em>]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT<small><sub>2</sub></small> (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action.
Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one
InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
ChemIDplus:87051-43-2
6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
ritanserinum
pubmed:18801405
ritanserin
NCIt:C95217
wikipedia.en:Ritanserin
cas:87051-43-2
chebi_ontology
pubmed:20825390
Reaxys:4913835
lincs.smallmolecule:LSM-2906
patent:US4533665
pubmed:8974378
R 55,667
KEGG DRUG:D05738
CiteXplore:8974378
CHEBI:64195
pubmed:11897543
reaxys:4913835
6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
ritanserina
CiteXplore:18801405
MESH:D016713
pubmed:12905101
kegg.drug:D05738
R-55667
ritanserine
C27H25F2N3OS
JUQLTPCYUFPYKE-UHFFFAOYSA-N
ChEMBL:110747
CiteXplore:12905101