chemical entity
methiothepin maleate
0
472.14905
472.632
pubmed:2142373
cas:19728-88-2
C20H24N2S2.C4H4O4
IWDBEHWZGDSFHR-BTJKTKAUSA-N
pubmed:554040
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (2Z)-but-2-enedioate
CiteXplore:18480175
CiteXplore:2138403
1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (2Z)-but-2-enedioate
CiteXplore:554040
1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazinediium (2Z)-but-2-enedioate
1-(10,11-Dihydro-8-(methylthio)dibenzo(b,f)thiepin-10-yl)-4-methylpiperazine maleate
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazinediium (2Z)-but-2-enedioate
A maleate salt obtained by reaction of methiothepin with one equivalent of maleic acid. Potent 5-HT<small><sub>2</sub></small> antagonist, also active as 5-HT<small><sub>1</sub></small> antagonist. Differentiates 5-HT<small><sub>1D</sub></small> sub-types. Also displays affinity for rodent 5-HT<small><sub>5B</sub></small>, 5-HT<small><sub>5A</sub></small>, 5-HT<small><sub>7</sub></small> and 5-HT<small><sub>6</sub></small> receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
CiteXplore:6448038
chebi_ontology
Reaxys:4119981
InChI=1S/C20H24N2S2.C4H4O4/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;5-3(6)1-2-4(7)8/h3-8,14,18H,9-13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
8-Methylthio-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin maleate
1-methyl-4-[8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine maleate
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine maleate
reaxys:4119981
1-methyl-4-[8-(methylsulfanyl)-10,11-dihydrodibenzo[b,f]thiepin-10-yl]piperazine (2Z)-but-2-enedioate
pubmed:6448038
pubmed:18480175
Metitepine maleate
pubmed:2138403
ChEMBL:882802
CHEBI:64202
CiteXplore:2142373
ChemIDplus:19728-88-2
CSc1ccc2c(c1)C(N1CCN(C)CC1)Cc1ccccc1S2.O=C(O)/C=CC(=O)O